Boosting the effects of vitamin D to tackle diabetes …


The investigators accomplished their goal by using an unexpected source: vitamin D. Vitamin D in cells and mouse models proved beneficial in treating damaged beta cells.
“In this study, we identified the vitamin D receptor as an important modulator of both inflammation and beta cell survival.”
Using beta cells created from embryonic stem cells, the investigators were able to identify a compound, iBRD9, that appeared to enhance the activation of the vitamin D receptor when it was combined with vitamin D to improve the survival of beta cells.
Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.
“By using a screening system that we developed in the lab, we’ve been able to identify an important piece of that puzzle that allows for super-activation of the Vitamin D pathway.”
Source: Boosting the effects of vitamin D to tackle diabetes …